2024

Van de Kooij, B., Van der Wal, F.J., Rother, M.B., Wiegant, W.W., Creixell, P., Stout, M., Joughin, B.A., Vornberger, J., Altmeyer, M., Van Vugt, M.A.T.M., Yaffe, M.B.* and Van Attikum, H.* (2024) The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks. Nat. Commun., doi: 10.1038/s41467-024-51090-6.

Llerena Schiffmacher, D.A., Lee, S.H., Kliza, K.W., Theil, A.F., Akita, M., Helfricht, A., Bezstarosti, K., Gonzalo-Hansen, C., Van Attikum, H., Verlaan-de Vries, M., Vertegaal, A.C.O., Hoeijmakers, J.H.J., Marteijn, J.A., Lans, H., Demmers, J.A.A., Vermeulen, M., Sixma, T.K., Ogi, T., Vermeulen, W. and Pines, A. (2024) The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics. Nat. Commun., doi: 10.1038/s41467-024-50584-7.

Chemo-Jadav, R., Weiland, F., Noordermeer, S.M., Carroll, T., Gao, Y., Wang, J., Zhou, H., Lamoliatte, F., Toth, R., Macartney, T., Brown, F., Hastie, C.J., Alabert, C., Van Attikum, H., Zenke, F., Masson, J.Y. and Rouse, J. (2024) Phosphoproteomic profiling with ATR inhibitors Berzosertib and Gartisertib uncovers new biomarkers and DNA damage response regulators. Mol. Cell. Proteomics., doi: 10.1016/j.mcpro.2024.100802.

Van de Kooij, B., Schreuder, A., Pavani, R., Garzero, V., Uruci, S., Wendel, T.J., Van Hoeck, A., San Martin Alonso, M., Everts, M., Koerse, D., Callen, E., Boom, J., Mei, H., Cuppen, E., Luijsterburg, M.S., Van Vugt, M.A.T.M., Nussenzweig, A., Van Attikum, H.* and Noordermeer, S.M.* (2024) EXO1 protects BRCA1-deficient cells against toxic DNA lesions. Mol. Cell., doi: 10.1016/j.molcel.2023.12.039.

2023

Smith, R., Zentout, S., Rother, M., Bigot, N., Chapuis, C., Mihuț, A., Zobel, F.F., Ahel, I., Van Attikum, H., Timinszky, G. and Huet, S. (2023) HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage. Nat. Struct. Mol. Biol., doi: 10.1038/s41594-023-00977-x.

2022

Van de Kooij, B., Kruswick, A., Van Attikum, H.* and Yaffe, N.B.* (2022) Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks. Nat. Commun., doi: 10.1038/s41467-022-32743-w.

Blessing, C., Apelt, K., Van den Heuvel D., Gonzalez-Leal, C., Rother, M.B., Van der Woude, M., González-Prieto, R., Yifrach, A., Parnas, A., Shah, R.G., Kuo, T.T., Boer, D.E.C., Cai, J., Kragten, A., Kim, H.S., Schärer, O.D., Vertegaal, A.C.O., Shah, G.M,. Adar, S., Lans, H., Van Attikum, H., Ladurner, A.G. and Luijsterburg, M.S. (2022) XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair. Nat. Commun., doi: 10.1038/s41467-022-31820-4.

Corbeski, I., Guo, X., Eckhardt, B.V., Fasci, D., Wiegant, W., Graewert, M.A., Vreeken, K., Wienk1, H., Svergun, D.I., Heck, Van Attikum, H., A.J.R., Boelens, R., Sixma, T.K., Mattiroli, F. and Van Ingen, H. (2022) Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF. Sci. Adv., doi: 10.1126/sciadv.abo0517.

Boonen, R.A.C.M., Vreeswijk, M.P.G. and Van Attikum, H. (2022) Functional analysis of genetic variants in CHEK2: towards improving cancer risk. Trends Cancer, doi: 10.1016/j.trecan.2022.04.009.

Van de Kooij, B. and Van Attikum, H. (2022) Genomic Reporter Constructs to Monitor Pathway-Specific Repair of DNA Double-Strand Breaks. Front Genet., doi: 10.3389/fgene.2021.809832.

Batté, A., Van der Horst, S.C., Tittel-Elmer, M., Sun, S.M., Sharma, S., Van Leeuwen, J., Chabes, A. and Van Attikum, H. (2022) Chl1 helicase controls replication fork progression by regulating dNTP pools. Life Sci Alliance, doi: 10.26508/lsa.202101153.

Boonen, R.A.C.M., Wiegant, W.W., Celosse, N., Vroling, B., Heijl, S., Kote-Jarai, Z., Mijuskovic, M., Cristea, S., Solleveld-Westerink, N., Van Wezel, T., Beerenwinkel, N., Eeles, R., Devilee, P., Vreeswijk, M.P.G., Marra, G. and Van Attikum H. (2022) Functional analysis identifies damaging CHEK2 missense variants associated with increased cancer risk. Cancer Res., doi: 10.1158/0008-5472.CAN-21-1845.

2021

Singh, J.K., Smith, R., Wiegant, W.W., Rother, M.B., Vreeken, K., D'Augustin, O., De Groot, A.J.L., González-Prieto, R., Vertegaal, A.C.O., Huet, S. and Van Attikum, H. (2021) Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining. Nat. Commun., doi: 10.1038/s41467-021-26691-0.

Katsuki, Y., Abe, M., Park, S.Y., Wu, W., Yabe, H., Yabe, M., Van Attikum, H., Nakada, S., Ohta, T., Seidman, M.M., Kim, Y. and Takata, M. (2021) RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair. Cell Rep., doi: 10.1016/j.celrep.2021.109879.

Baas, R. J., Van der Wal, F., Bleijerveld, O.B., Van Attikum, H. and Sixma, T.K. (2021) Proteomic analysis identifies novel binding partners of BAP1. PLoS One, doi: 10.1371/journal.pone.0257688.

Pulver, E.M., Mukherjee, C., Van de Kamp, G., Roobol, S.J., Rother, M.B., Van der Gulden, H., De Bruijn, R., Lattanzio, M.V., Van der Burg, E., Drenth, A.P., Verkaik, N.S., Hahn, K., Klarenbeek, S., De Korte-Grimmerink, R., Van de Ven, M., Pritchard, C.E.J., Huijbers, IJ., Xia, B., Van Gent, D.C., Essers, J., Van Attikum, H., Ray Chaudhuri, A., Bouwman, P. and Jonkers, J. (2021) A BRCA1 coiled-coil domain variant disrupting PALB2 interaction promotes the development of mammary tumors and confers a targetable defect in homologous recombination repair. Cancer Res., doi: 10.1158/0008-5472.

Kollenstart L., Janssen, G.M.C., Van Veelen, P.A. and Van Attikum, H. (2021) Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies. Sci. Rep., doi: 10.1038/s41598-021-91359-0.

Ng, P.S., Boonen, R.A., Wijaya, E., Chong, C.E., Sharma, M., Knaup, S., Mariapun, S., Ho, W.K., Lim, J., Yoon, S-Y., Mohd Taib, N.A., See, M.H., Li, J., Lim, S.H., Tan, E.Y., Tan, B.K.T., Tan, S-M., Tan, V.K.M., Van Dam, R.M., Rahmat, K., Yip, C.H., Carvalho, S., Luccarini, C., Baynes, C., Dunning, A.M., Antoniou, A.C., Van Attikum, H., Easton, D.F., Hartman, M. and Teo, S.H. (2020) Characterisation of protein-truncating and missense variants in PALB2 in 15,768 women from Malaysia and Singapore. J. Med. Genet., doi: 10.1136/jmedgenet-2020-107471.

2020

Pfeiffer, A., Herzog, L.K., Luijsterburg, M.S., Shah, R.G., Rother, M.B., Stoy, H., Kühbacher, U., Van Attikum, H., Shah, G.M., and Dantuma, N.P. (2019) Poly(ADP-ribos)ylation limits SUMO-dependent ataxin-3 recruitment to DNA double-strand breaks to the early phase of the DNA damage response. J. Cell Sci., doi: 10.1242/jcs.247809.

Apelt, K., White, S.M., Kim, H.S., Yeo, J.E., Kragten, A., Wondergem, A.P., Rooimans, M.A., González-Prieto, R., Wiegant, W.W., Lunke, S., Flanagan, D., Pantaleo, S., Quinlan, C., Hardikar, W., Van Attikum H., Vertegaal, A.C.O., Wilson, B.T., Wolthuis, R.M.F., Schärer, O.D. and Luijsterburg, M.S. (2021) ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients. J. Exp. Med., doi: 10.1084/jem.20200622.

Boonen, R.A.C.M., Vreeswijk, M.P.G., and Van Attikum H. (2020) Functional Characterization of PALB2 Variants of Uncertain Significance: toward cancer risk and therapy response prediction. Front. Mol. Biosci., doi: 10.3389/fmolb.2020.00169.

Rother, M.B., Pellegrino, S., Smith, R., Gatti, M., Meisenberg, C., Wiegant, W.W., Luijsterburg, M.S., Imhof, R., Downs, J.A., Vertegaal, A.C.O., Huet, S., Altmeyer, M. and Van Attikum, H. (2020) CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks. Nat. Commun., doi.org/10.1038/s41467-020-19502-5.

Singh, J.K. and Van Attikum, H. (2020) DNA double-strand break repair: Putting zinc fingers on the sore spot. Semin. Cell Dev. Biol., doi: 10.1016/j.semcdb.2020.09.003.

Helfricht, A., Thijssen, P.E., Rother, M.B., Shah, R.G., Du, L., Takada, S., Rogier, M., Moritz, J., IJspeert, H., Stoepker, C., van Ostaijen-Ten Dam, M.M., Heyer, V., Luijsterburg, M.S., de Groot, A., Jak, R., Grootaers, G., Wang, J., Rao, P., Vertegaal, A.C.O., van Tol, M.J.D., Pan-Hammarström, Q., Reina-San-Martin, B., Shah, G.M., van der Burg, M., van der Maarel, S.M. and Van Attikum, H. (2020) Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome. J. Exp. Med., doi: 10.1084/jem.20191688.

Sun S.M., Batté, A., Elmer, M., van der Horst, S.C., van Welsem T., Bean, G., Ideker, T., van Leeuwen, F. and Van Attikum H. (2020) A genetic interaction map centered on cohesin reveals auxiliary factors involved in sister chromatid cohesion in S. cerevisiae. J. Cell Sci., doi: 10.1242/jcs.237628.PMID: 32299836.

Alonso-de Vega, I, Paz, C., Wiegant, W.W., Checa-Rodríguez, C., Huertas, P., Freire, R., Van Attikum, H. and Smits, V.A.J. (2020) PHF2 regulates homology-directed DNA repair by controlling the resection of double strand breaks. Nucleic. Acids. Res., doi: 10.1093/nar/gkaa196.

Warmerdam, D.O., Alonso-de Vega, I., Wiegant, W.W., van den Broek, B., Rother, M.B., Wolthuis, R.M., Freire, R., Van Attikum, H., Medema, R.H. and Smits, V.A. (2020) PHF6 promotes non-homologous end joining and G2 checkpoint recovery. EMBO Rep., doi: 10.15252/embr.201948460.

2019

Boonen, R.A.C.M., Rodrigue, A., Stoepker, C., Wiegant, W.W., Vroling, B., Sharma, M., Rother, M.B., Celosse, N., Vreeswijk, M.P.G., Couch, F., Simard, J., Devilee, P., Masson, J-Y. and Van Attikum, H. (2019) Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2. Nat. Commun.,doi: 10.1038/s41467-019-13194-2.

Kollenstart, K., De Groot, A.J.L, Janssen, G.M.C, Cheng, X., Vreeken, K., Martino, F., Côté, J., Van Veelen, P.A. and Van Attikum, H. (2019) Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription. J. Biol. Chem., doi: 10.1074/jbc.RA119.010302.

Caron, P., Van der Linden, J and Van Attikum, H. (2019) Bon voyage: a transcriptional journey around DNA breaks. DNA Repair, doi: 10.1016/j.dnarep.2019.102686.

Noordermeer, S.M#. and Van Attikum, H.# (2019) PARP inhibitor resistance: a tug-of-war in BRCA-mutated cells. Trends Cell Biol., doi: 10.1016/j.tcb.2019.07.008 (# co-corresponding author).

Rabl, J., Bunker, R.D., Schenk, A.D., Cavadini, S., Gill, M.E., Abdulrahman, W., Andrés-Pons, A., Luijsterburg, M.S., Ibrahim, A.F.M., Branigan, E., Aguirre, J.D., Marceau, A.H., Guérillon, C., Bouwmeester, T., Hassiepen, U., Peters, A.H.F.M., Renatus, M., Gelman, L., Rubin, S.M., Mailand, N., Van Attikum, H., Hay, R.T., Thomä, N.H. (2019) Structural basis of BRCC36 function in DNA repair and immune regulation. Mol Cell., doi: 10.1016/j.molcel.2019.06.002.

Caron, P., Pankotai, T., Wiegant, W.W., Tollenaere, M.A.X., Furst, A., Bonhomme, C., Helfricht, A., De Groot, A., Pastink, A., Vertegaal, A.C.O., Luijsterburg, M.S., Soutoglou, E., and Van Attikum H. (2019) WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks. Genes Dev.., doi: 10.1101/gad.321943.118.

Moore, S., Berger, N.D., Luijsterburg, M.S., Piett, C.G., Stanley, F.K.T., Schräder, C.U., Fang, S., Chan, J.A., Schriemer, D.C., Nagel, Z.D., Van Attikum H., and Goodarzi, A.A. (2019) The CHD6 chromatin remodeler is an oxidative DNA damage response factor. Nat. Commun., doi: 10.1038/s41467-018-08111-y.

2018

Van Welsem, T., Korthout, T., Ekkebus, R., Morais, D., Molenaar, T.M., Van Harten, K., Poramba-Liyanage, D.W., Sun, S.M., Lenstra, T.L., Srivas, R., Ideker T., Holstege, F.C.P., Van Attikum, H., El Oualid, F., Ovaa, H., Stulemeijer, I.J.E., Vlaming, H. and Van Leeuwen F. (2018) Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism. Nucleic Acids Res., doi: 10.1093/nar/gky801.

Noordermeer, S.M*, Adam, S., Setiaputra, D, Barazas, M., Pettitt, S.J., Ling, A.K., Olivieri, M., Álvarez-Quilón, A., Moatti, N., Zimmermann, M., Annunziato, S., Krastev, D.B., Song, F., Brandsma, I., Frankum, J., Brough, R., Sherker, A., Landry, S., Szilard, R.K., Munro, M.M., McEwan, A., Goullet de Rugy, T., Lin, Z., Hart, T., Moffat, J., Gingras, A., Martin, A., Van Attikum, H., Jonkers, J., Lord, C.J., Rottenberg, S. and Durocher, D. (2018) The SHIELDIN complex mediates 53BP1-dependent DNA repair. Nature, 560: 117-121 (IF 41.5) (* first author from my laboratory).

Gogola, E, Duarte, A.A., De Ruiter, J.R., Wiegant, W.W., Schmid, J.A., De Bruijn, R., James, D.I., Guerrero Llobet, S., Vis, D.J., Annunziato, S., Van den Broek, B., Barazas, M., Kersbergen, A., Van de Ven, M., Tarsounas, M., Ogilvie, D.J., Van Vugt, M., Wessels, L.F.A., Bartkova, J., Gromova, I., Andújar-Sánchez, M., Bartek, J., Lopes, M., Van Attikum, H., Borst, P., Jonkers, J. and Rottenberg, S. (2018) Selective loss of PARG restores PARylation and counteracts PARP inhibitor-mediated synthetic lethality. Cancer Cell, 33: 1078-1093.

Velimezi, G., Robinson-Garcia, L., Muñoz-Martínez, F., Wiegant, W.W., Ferreira da Silva, J., Owusu, M., Moder, M., Wiedner, M., Rosenthal, S.B., Fisch, K.M., Moffat, J., Menche, J., Van Attikum, H., Jackson, S.P. and Loizou J.I. (2018) Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48. Nat. Commun., doi: 10.1038/s41467-018-04649-z.

Pines, P.*, Dijk, P.*, Makowski, M., Meulenbroek, E.M., Vrouwe, M.G., Van der Weegen, Y., Baltissen, M., French, P.J., Van Royen, M.E., Luijsterburg, M.S., Mullenders, L.H., Vermeulen, M., Vermeulen, W., Pannu N.S. and Van Attikum, H. (2018) TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A. Nat. Commun., doi:10.1038/s41467-018-03484-6.

2017

Kochan, J.A., Desclos, E.C.B., Bosch, R., Meister, L., Vriend, L.E.M., Van Attikum, H. and Krawczyk, P.M. (2017) Meta-analysis of DNA double-strand break response kinetics. Nucleic. Acids. Res., 45: 12625-12637.

Toonen, L.J.A., Rigo, F., Van Attikum, H. and Van Roon-Mom, W.M.C. (2017) Antisense oligonucleotide mediated removal of the polyglutamine repeat from the ataxin-3 protein in a mouse model of SCA3. Mol. Ther. Nucleic Acids, 8: 232-242.

Rother-Krawitowska, M. and Van Attikum, H. (2017) SMARCA and CHD chromatin remodelers in DNA repair and human disease. Philos. Trans. B., doi: 10.1098/rstb.2016.0285.

Pfeiffer, A.*, Luijsterburg, M.S.*, Acs, K., Wiegant, W.W., Helfricht, A., Herzog, L.K., Minoia, M., Böttcher, C., Salomons, F.A., Van Attikum, H.# and Dantuma, N.# (2017) Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4. EMBO J., 36: 1066-1083 (* co-first author from my laboratory, # co-corresponding author).

Luijsterburg, M.S., Typas, D., Caron, M.C., Wiegant, W.W., Van den Heuvel, D., Boonen, R.A., Couturier, A.M., Mullenders, L.H., Masson, J.Y. and Van Attikum, H. (2017) A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation. eLife, 6:e20922.

2016

Spruijt C.G*., Luijsterburg M.S.*, Menafra, R., Lindeboom, R.G.H., Jansen, P.W.T.C., Edupuganti, R.R., Baltissen, M.P., Voelker-Albert, M.C., Matarese, F., Mensinga, A., Poser, I., Vos, H.R., Stunnenberg, H.G#., Van Attikum, H.# and Vermeulen, M.# (2016) ZMYND8 co-localizes with NuRD on target genes and regulates recruitment of GATAD2A/NuRD to sites of DNA damage. Cell Rep., 17: 783-798 (* co-first author from my laboratory, # co-corresponding author).

Toonen, L.J., Schmidt, I, Luijsterburg, M.S., Van Attikum, H. and Van Roon-Mom, W.M. (2016) Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3. Sci. Rep., 6: 35200.

Srivas, R., Shen, J.P., Yang, C.C. Sun, S.M. Li, J., Gross, A.M., Jensen, J., Licon, K., Bojorquez-Gomez, A., Klepper, K., Huang, J., Pekin, D., Xu, J.L., Yeerna, H., Sivaganesh, V., Kollenstart, L., Van Attikum, H., Aza-Blanc, P., Sobol, R.W. and Ideker, T. (2016) A network of conserved synthetic lethal interactions for exploration of precision cancer therapy. Mol. Cell, 63: 514-524.

Hilbers, F.S., Luijsterburg, M.S., Wiegant, W.W., Meijers, C.M., Völker-Albert, M., Boonen, R.A., Van Asperen, C.J., Devilee, P. and Van Attikum, H. (2016) Functional analysis of missense variants in the putative breast cancer susceptibility gene XRCC2. Hum. Mutat.. 37:914-925.

Luijsterburg, M.S., De Krijger, I., Wiegant, W.W., Shah, R.G., Smeenk, G., De Groot, A.J.L., Pines, A., Vertegaal, A.C.O., Jacobs, J.J.L., Shah, G.M. and Van Attikum, H. (2016) PARP1 links CHD2-mediated chromatin expansion and H3.3 deposition to DNA repair by non-homologous end-joining. Mol. Cell, 18: 547-562.

Dantuma, N. and Van Attikum, H. (2016) Spatiotemporal regulation of post-translational modifications in the DNA damage response. EMBO. J., 35: 6-23.

Shen, J.P., Srivas, R., Gross, A., Li, J., Jaehnig, E.J., Sun, S.M., Bojorquez-Gomez, A., Licon, K., Sivaganesh, V., Xu, J.L., Klepper, K., Yeerna, H., Pekin, D., Qiu, C.P., Van Attikum, H., Sobol, R.W. and Ideker, T. (2016) Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition. Oncotarget, 6: 35755-35769.

2015

Typas, D., Luijsterburg, M.S., Wiegant, W.W., Helfricht, A., Van den Broek, B., Diakatou, M., Thijssen, P.E., Mullenders, L.H. and Van Attikum, H. (2015). The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80. Nucleic Acids Res., 18: 6919-1933.

González-Prieto, R., Cuijpers, S.A., Luijsterburg, M.S., Van Attikum, H. and Vertegaal, A.C.O. (2015) SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites. EMBO Rep., 16: 512-519.

2014

Klement, K.*, Luijsterburg, M.S.*, Pinder, J.B., Cena, C.S., Del Nero, V., Wintersinger, C.M., Dellaire, G., Van Attikum, H. and Goodarzi, A.A. (2014) Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair. J. Cell. Biol., 207, 717-733 (* co-first author from my laboratory).

Hustedt, N., Seeber, A., Sack, S., Tsai-Pflugfelder, M., Bhullar, B., Vlaming, H., Van Leeuwen, F., Guénolé, A., Van Attikum, H., Srivas, R., Ideker, T., Shimada, K. and Gasser, S.M. (2014) Yeast PP4 interacts with ATR homologue Ddc2-Mec1 and regulates checkpoint signaling. Mol. Cell, 57, 273-28.

Helfricht, A. and Van Attikum, H. (2014). Remodeling and spacing factor 1 (RSF1): a rising star in DNA repair. Epigenomics, 6, 261-265.

Aydin, Ö.Z., Marteijn, J.A., Ribeiro-Silva, C., Rodríguez López, A., Wijgers, N., Smeenk, G., Van Attikum, H., Poot, R.A., Vermeulen, W. and Lans, H. (2014) Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription. Nucleic Acids Res., 42, 8473-8485.

2013

Srivas, R*., Costelloe, T.*, Carvunis, A-R., Sarkar, S., Malta, E., Sun, S.M., Pool, M., Licon, K., Van Welsem, T., Van Leeuwen, F., McHugh, P.J., Van Attikum, H.# and Ideker, T.# (2013) A UV–induced genetic network links the RSC complex to nucleotide excision repair and displays dose-dependent rewiring. Cell Rep., 5, 1714-1724 (* co-first author from my laboratory, # co-corresponding author).

Helfricht, A., Wiegant, W.W., Thijssen, P.E., Vertegaal, A.C., Luijsterburg, M.S. and Van Attikum H. (2013) Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining. Cell Cycle, 12, 3070-82.

Pines, A., Mullenders, L.H., Van Attikum H. and Luijsterburg, M.S. (2013) Touching base with PARPs: moonlighting in the repair of UV lesions and double-strand breaks. Trends Biochem Sci., 38, 321-330.

Smeenk, G. and Van Attikum, H. (2013) The chromatin response to DNA breaks: leaving a mark on genome integrity. Annu. Rev. Biochem., 82, 55-80.

Guénolé, A., Srivas, R., Vreeken, K., Wang, Z.Z., Wang, S., Krogan, N.J., Ideker, T. and Van Attikum, H. (2013) Dissection of DNA damage responses using multi-conditional genetic interaction maps. Mol. Cell., 24, 346-358 (Issue highlight).

Smeenk, G., Wiegant, W.W., Marteijn, J.A., Luijsterburg, M.S., Sroczynski, N., Costelloe, T., Romeijn, R.J., Pastink, A., Mailand, N., Vermeulen, W. and Van Attikum H. (2013) Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling. J. Cell Sci., 126, 889-903.

2012

Vyas, R., Kumar, R., Clermont, F., Helfricht, A., Kalev, P., Sotiropoulou, P., Hendriks, I.A., Radaelli, E., Hochepied, T., Blanpain, C., Sablina, A., Van Attikum, H., Olsen, J.V., Jochemsen, A.G., Vertegaal, A.C. and Marine, J.C. (2012) RNF4 is required for DNA double-strand break repair in vivo. Cell Death Differ., 20, 490-502.

Neumayer, G., Helfricht, A., Shim, S.Y., Le, H.T., Lundin, C., Belzil, C., Chansard, M., Yu, Y., Lees-Miller, S.P., Gruss, O.J., Van Attikum, H., Helleday, T. and Nguyen, M.D. (2012) Targeting protein for Xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation. J. Biol Chem., 287, 42206-42222.

Santen, G.W., Kriek, M. and Van Attikum, H. (2012) SWI/SNF complex in disorder: SWItching from malignancies to intellectual disability. Epigenetics, 7, 1219 - 1224.

Costelloe,T*., Louge, R., Tomimatsu, N., Mukherjee, B., Martini, E., Khadaroo, B., Dubois, K., Wiegant, W.W., Thierry, A., Burma, S., Van Attikum, H.#, and Llorente, B.# (2012) The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end-resection. Nature, 489, 581 – 584 (* first author from my laboratory, # co-corresponding author).

Hegnauer, A.M., Hustedt, N., Shimada, K., Pike, B.L., Vogel, M., Amsler, P., Rubin, S.M., Van Leeuwen, F., Guénolé, A., Van Attikum, H., Thomä, N.H. and Gasser, S.M. (2012) An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 to stalled forks. EMBO J., 31, 3768-3783.

Luijsterburg, M.S., Acs, K., Ackermann, L., Wiegant, W.W., Bekker-Jensen, S., Larsen, D.H., Khanna, K.K., Van Attikum, H., Mailand, N. and Dantuma, N.P. (2012) A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure. EMBO J., 31, 2511-1537.

Luijsterburg, M.S., Lindh, M., Acs, K., Vrouwe, M.G., Pines, A., Van Attikum, H., Mullenders, L.H. and Dantuma, N.P. (2012) DDB2 promotes chromatin decondensation at UV-induced DNA damage. J. Cell Biol., 197, 267-281.

Luijsterburg, M.S. and Van Attikum, H. (2012) Close encounters of the RNF8th kind: when chromatin meets DNA repair. Curr. Opin. Cell. Biol., 24, 439-447.

2011

Smeenk, G. and Van Attikum, H. (2011) NuRD alert! NuRD regulates the DNA damage response. Epigenomics, doi: 10.2217/epi.10.79.

Luijsterburg, M.S. and Van Attikum, H. (2011) Chromatin and the DNA damage response: the cancer connection. Mol. Oncol., 5, 349-367.

Ryan, C., Greene, D., Guénolé, A., Van Attikum, H., Krogan, N.J., Cunningham, P. and Cagney, G. (2011) Improved functional overview of protein complexes using inferred epistatic relationships. BMC Syst. Biol., 5, 80.

2010

Bandyopadhyay, S., Mehta, M., Kuo, D., Sung, M.K., Chuang, R., Jaehnig, E.J., Bodenmiller, B., Licon, K., Copeland, W., Shales, M., Fiedler, D., Dutkowski, J., Guénolé, A., Van Attikum, H., Shokat, K.M., Kolodner, R.D., Huh, W.K., Aebersold, R., Keogh, M.C., Krogan, N.J. and Ideker, T. (2010) Rewiring of genetic networks in response to DNA damage. Science, 330, 1385-1389.

Smeenk, G., Wiegant, W.W., Vrolijk, H., Solari, A.P., Pastink, A. and Van Attikum, H. (2010) The NuRD chromatin remodeling complex regulates signaling and repair of DNA damage. J. Cell Biol., 190, 741-749.

Cobb, J. and Van Attikum, H. (2010) Mapping genomic targets of DNA helicases by chromatin immunoprecipitation in Saccharomyces cerevisiae. Methods Mol. Biol., 587, 113-26.

2009

Hannum, G., Srivas, R., Guénolé, A., Van Attikum, H., Krogan, N.J., Karp, R.M. and Ideker, T. (2009) Genome-wide association data reveal a global map of genetic interactions among protein complexes. Plos Genet., 5, e1000782.

Van Attikum, H. and Gasser, S.M. (2009) Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol., 19, 207-217.

2008

Bystricky, K., Van Attikum, H., Montiel, M.D., Dion, V., Gehlen, L. and Gasser, S.M. (2008) Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70/Ku80 complex. Mol. Cell. Biol., 29, 835-848.

2007

Dubrana, K., Van Attikum, H., Hediger, H. and Gasser, S.M. (2007) The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast. J. Cell Sci., 120, 4209-4220.

Van Attikum, H., Fritsch, H. and Gasser, S.M. (2007) Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks. EMBO J., 26, 4113 – 4125.

2006

West, A and Van Attikum, H. (2006) Chromatin at the crossroads. Meeting on signalling to chromatin epigenetics. EMBO Rep., 7, 1206-1210.

Hooykaas, P.J.J., Den Dulk-Ras, A., Bundock, A., Soltani, J., Van Attikum, H. and Van Heusden, P. (2006) Yeast (Saccharomyces cerevisiae). Methods Mol. Biol., 334, 456-473.

2005

Van Attikum, H. and Gasser, S.M. (2005) The histone code at DNA breaks: a guide to repair? Nat. Rev. Mol. Cell Biol., 6, 757-765.

Van Attikum, H. and Gasser, S.M. (2005) ATP-dependent chromatin remodeling and DNA double-strand break repair. Cell Cycle, 4, 1011-1014.

2004

Van Attikum, H., Fritsch, O. and Gasser, S.M. (2004) Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. Cell, 119, 777-788.

2003

Van Attikum, H., Bundock,P., Overmeer, R.M., Lee, L-Y., Gelvin, S.B. and Hooykaas, P.J.J. (2003) The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNA. Nucleic Acids Res., 31, 4247-4255.

Van Attikum, H. and Hooykaas, P.J.J. (2003) Genetic requirements for the targeted integration of Agrobacterium T-DNA in Saccharomyces cerevisiae. Nucleic Acids Res., 31, 826-832.

2002

Bundock, P., Van Attikum, H. and Hooykaas, P.J.J. (2002) Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant. Nucleic Acids Res., 30, 3395-3400.

2001

Bundock, P., Van Attikum, H. and Hooykaas, P.J.J. (2001) Insertional mutagenesis in yeast using T-DNA from Agrobacterium tumefaciens. Yeast, 19, 529-536.

Van Attikum, H., Bundock, B. and Hooykaas, P.J.J. (2001) Non-homologous end-joining proteins are required for Agrobacterium T-DNA integration. EMBO J., 20, 6550-6558.